PDK2

Across TCGA pan-cancer cohorts, PDK2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PDK2 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PDK2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PDK2 expression acts as an unfavorable survival marker, although some lineages such as COAD and OV show a favorable association.

COAD, OV, and LUAD are the cancer types where PDK2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.911	.015	18	view →
OV	DFS	Tertile	All	0.922	0.535	.045	8	view →
LUAD	DFS	Median	All	0.840	0.954	.024	7	view →
CCRCC	DFS	Median	III,IV	0.818	0.244	.031	6	view →
UCEC	OS	Median	III,IV	0.461	0.915	.047	4	view →
HNSC	DFS	Tertile	III,IV	0.901	0.690	.028	3	view →
LSCC	DFS	Median	All	0.905	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PDK2–COAD (DFS)

Open the COAD breakdown →