PDK2

Across TCGA patient cohorts, PDK2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,860 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PDK2-associated genes across cancer lineages are TMSB10, PLAUR, and CXCL8. Each is linked with PDK2 in more than 6 cancer types. Because this analysis shows association rather than direction, both PDK2-to-partner and partner-to-PDK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDK2 versus TMSB10 in BRCA, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDK2→partner) and Y-score (partner→PDK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMSB10 →	-0.869	-0.478	<.001	<.001	3	7
GBM	PLAUR →	-0.799	-0.296	.005	.005	3	6
LUAD	CXCL8 →	-1.941	-0.371	<.001	<.001	3	6
COAD	PFN1 →	-0.525	-0.311	<.001	<.001	3	6
HNSC	TSPAN7 →	+1.687	+0.448	<.001	<.001	3	5
BRCA	ANLN →	-0.982	-0.555	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,860 associations by consensus.

PDK2 vs TMSB10 — BRCA

Explore this scatter interactively →