PDK2

Across TCGA patient cohorts, PDK2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDK2-associated genes across cancer lineages are Lck, Myosin-IIa_pS1943, and Myosin-IIa. Each is linked with PDK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDK2-to-partner and partner-to-PDK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by PDK2-low versus PDK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDK2→partner) and Y-score (partner→PDK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.289	+3.459	.004	.005	3	1
UCEC	Myosin-IIa_pS1943 →	+0.245	+3.472	.018	.002	3	1
UCEC	Myosin-IIa →	+0.288	+3.010	.001	.019	3	1
UCEC	PDK1_pS241 →	+0.194	+2.335	.023	.020	3	1
UCEC	Annexin-1 →	+0.737	+3.189	.005	.010	3	1
UCEC	Shc_pY317 →	-0.207	-3.459	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Lck by PDK2 expression — UCEC

Explore this box plot interactively →