PDK2

Across TCGA cell cohorts, PDK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,993 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PDK2-associated GO terms across cancer lineages are Cilium-dependent cell motility, Cilium or flagellum-dependent cell motility, and Protein stabilization. Each is linked with PDK2 in more than 12 cancer types. Because this analysis shows association rather than direction, both PDK2-to-partner and partner-to-PDK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cilium-dependent cell motility grouped by PDK2-low versus PDK2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDK2→partner) and Y-score (partner→PDK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.113	-0.809	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.113	-0.809	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Protein stabilization →	+0.055	+0.922	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.108	-0.863	<.001	<.001	3	11
STOMACH	Cellular response to morphine →	+0.208	+1.043	.001	.004	2	12
STOMACH	Cellular response to isoquinoline alkaloid →	+0.208	+1.043	.001	.004	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,993 associations by consensus.

Cilium-dependent cell motility by PDK2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →