PDK1

Across TCGA pan-cancer cohorts, PDK1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PDK1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PDK1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PDK1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

CCRCC, LUAD, and UCEC are the cancer types where PDK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	0.426	0.931	<.001	43	view →
LUAD	DFS	Tertile	II,III,IV	0.866	0.283	.016	16	view →
UCEC	DFS	Tertile	II,III,IV	0.889	0.460	.048	4	view →
GBM	OS	Median	All	0.289	0.505	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PDK1–CCRCC (OS)

Open the CCRCC breakdown →