PDK1

Across TCGA patient cohorts, PDK1 mutation is significantly associated with the RNA expression of many other genes, with 469 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDK1-associated genes across cancer lineages are RNU6-1286P, CDH12P2, and MIR4510. Each is linked with PDK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDK1-to-partner and partner-to-PDK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1286P grouped by PDK1-low versus PDK1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDK1→partner) and Y-score (partner→PDK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1286P →	+0.368	+7.954	<.001	.008	3	3
HNSC	CDH12P2 →	+0.154	+7.954	<.001	.008	3	2
CESC	MIR4510 →	+0.400	+6.342	<.001	.001	3	2
UCEC	RNU6-65P →	+0.264	+3.453	<.001	.003	3	2
UCEC	IGLV2-8 →	+2.451	+3.330	<.001	.005	3	1
UCEC	MIR6857 →	+0.293	+2.899	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 469 associations by consensus.

RNU6-1286P by PDK1 expression — HNSC

Explore this box plot interactively →