PDK1

Across TCGA cell cohorts, PDK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,453 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDK1-associated GO terms across cancer lineages are Hypoxia-inducible factor-1alpha signaling pathway, Regulation of acyl-CoA biosynthetic process, and Regulation of pyruvate decarboxylation to acetyl-CoA. Each is linked with PDK1 in more than 18 cancer types. Because this analysis shows association rather than direction, both PDK1-to-partner and partner-to-PDK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Hypoxia-inducible factor-1alpha signaling pathway grouped by PDK1-low versus PDK1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDK1→partner) and Y-score (partner→PDK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Hypoxia-inducible factor-1alpha signaling pathway →	+1.262	+1.475	<.001	<.001	3	19
KIDNEY	Regulation of acyl-CoA biosynthetic process →	+0.143	+1.277	<.001	.003	3	15
KIDNEY	Regulation of pyruvate decarboxylation to acetyl-CoA →	+0.143	+1.277	<.001	.003	3	15
SKIN	Regulation of sulfur metabolic process →	+0.109	+1.217	<.001	<.001	3	13
URINARY_TRACT	Glycolytic process through fructose-6-phosphate →	+0.137	+1.505	.001	<.001	3	11
URINARY_TRACT	Glycolytic process through glucose-6-phosphate →	+0.137	+1.505	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,453 associations by consensus.

Hypoxia-inducible factor-1alpha signaling pathway by PDK1 expression — LIVER

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