PDIA5

Across TCGA patient cohorts, PDIA5 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDIA5-associated genes across cancer lineages are eEF2, eIF4E, and mTOR_pS2448. Each is linked with PDIA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDIA5-to-partner and partner-to-PDIA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PDIA5-low versus PDIA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDIA5→partner) and Y-score (partner→PDIA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.412	+2.999	.013	.035	3	2
UCEC	eIF4E →	+0.274	+3.700	.005	.001	3	2
UCEC	mTOR_pS2448 →	-0.158	-3.150	.023	.019	3	2
UCEC	14-3-3_beta →	-0.109	-2.973	.019	.035	3	1
UCEC	ERK2 →	+0.181	+3.169	.043	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.153	-3.312	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eEF2 by PDIA5 expression — UCEC

Explore this box plot interactively →