PDIA5

Across TCGA cell cohorts, PDIA5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,520 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDIA5-associated GO terms across cancer lineages are Multi-pass transmembrane protein insertion into ER membrane, Post-translational protein targeting to membrane, translocation, and Protein N-linked glycosylation. Each is linked with PDIA5 in more than 11 cancer types. Because this analysis shows association rather than direction, both PDIA5-to-partner and partner-to-PDIA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Multi-pass transmembrane protein insertion into ER membrane grouped by PDIA5-low versus PDIA5-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDIA5→partner) and Y-score (partner→PDIA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Multi-pass transmembrane protein insertion into ER membrane →	+0.171	+2.137	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Post-translational protein targeting to membrane, translocation →	+0.107	+0.973	<.001	.001	3	10
SOFT_TISSUE	Protein N-linked glycosylation →	+0.062	+1.032	<.001	<.001	3	10
BLOOD_Lymphoma	Regulation of protein exit from endoplasmic reticulum →	+0.086	+1.273	.001	.005	3	10
LIVER	Positive regulation of protein exit from endoplasmic reticulum →	+0.151	+1.263	<.001	<.001	3	10
OESOPHAGUS	Cotranslational protein targeting to membrane →	+0.157	+1.103	.002	.006	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,520 associations by consensus.

Multi-pass transmembrane protein insertion into ER membrane by PDIA5 expression — BLOOD_Lymphoma

Explore this box plot interactively →