PDIA5

Across TCGA cell cohorts, PDIA5 mutation is significantly associated with the RNA expression of many other genes, with 327 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDIA5-associated genes across cancer lineages are C10orf67, FCN1, and SEPTIN3. Each is linked with PDIA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDIA5-to-partner and partner-to-PDIA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf67 grouped by PDIA5-low versus PDIA5-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDIA5→partner) and Y-score (partner→PDIA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C10orf67 →	+0.017	+4.285	<.001	.003	3	1
BLOOD_Myeloma	FCN1 →	+0.127	+4.754	<.001	<.001	3	1
LARGE_INTESTINE	SEPTIN3 →	+1.177	+3.299	.004	.004	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.607	+3.212	.003	.006	3	1
LARGE_INTESTINE	C1QBP →	+0.745	+3.299	.001	.004	3	1
LARGE_INTESTINE	MED31 →	+0.622	+3.212	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 327 associations by consensus.

C10orf67 by PDIA5 expression — BLOOD_Myeloma

Explore this box plot interactively →