Across TCGA patient cohorts, PDIA2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,323 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PDIA2-associated genes across cancer lineages are GRK6, WDR46, and NBPF9. Each is linked with PDIA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDIA2-to-partner and partner-to-PDIA2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDIA2→partner) and Y-score (partner→PDIA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GRK6 →	-0.731	-0.865	<.001	.003	3	3
OV	WDR46 →	-0.526	-0.815	.001	.002	3	3
OV	NBPF9 →	-0.700	-0.768	.007	.009	3	3
GBM	BEST1 →	+0.619	+0.832	<.001	<.001	3	2
HNSC	MIR217 →	+1.292	+1.447	.001	<.001	3	2
HNSC	MIR4648 →	+1.402	+1.162	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,323 associations by consensus.

Exploration

PDIA2 survival (RNA) · tumor vs normal (RNA) · all PDIA2 data types