Across TCGA patient cohorts, PDIA2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PDIA2-associated genes across cancer lineages are 14-3-3_zeta, Bax, and Caspase-7-cleavedD198. Each is linked with PDIA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDIA2-to-partner and partner-to-PDIA2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDIA2→partner) and Y-score (partner→PDIA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_zeta →	+0.216	+2.196	.046	.034	3	1
UCEC	Bax →	+0.303	+3.321	.016	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.696	+2.827	.025	.035	3	1
COAD	TAZ →	+0.349	+2.832	.001	.035	3	1
COAD	HSP70 →	+0.663	+2.815	.033	.036	1	1
COAD	PAI-1 →	+1.140	+2.815	<.001	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

PDIA2 survival (RNA) · tumor vs normal (RNA) · all PDIA2 data types