PDHX

Across TCGA patient cohorts, PDHX protein abundance is significantly associated with the protein abundance of many other proteins, with 23,673 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PDHX-associated proteins across cancer lineages are RTN4IP1, SDHA, and SDHB. Each is linked with PDHX in more than 9 cancer types. Because this analysis shows association rather than direction, both PDHX-to-partner and partner-to-PDHX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDHX versus RTN4IP1 in BRCA, with a Pearson correlation of 0.36.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDHX→partner) and Y-score (partner→PDHX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RTN4IP1 →	+0.440	+0.400	<.001	<.001	3	10
GBM	SDHA →	+0.367	+0.415	<.001	<.001	3	10
GBM	SDHB →	+0.355	+0.431	<.001	<.001	3	10
OV	TIMM44 →	+0.541	+0.497	<.001	<.001	3	10
OV	TUFM →	+0.332	+0.301	<.001	<.001	3	10
GBM	PDHA1 →	+0.560	+0.540	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,673 associations by consensus.

PDHX vs RTN4IP1 — BRCA

Explore this scatter interactively →