PDHX

Across TCGA patient cohorts, PDHX mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDHX-associated genes across cancer lineages are FoxM1, MEK1, and PCNA. Each is linked with PDHX in more than 1 cancer types. Because this analysis shows association rather than direction, both PDHX-to-partner and partner-to-PDHX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by PDHX-low versus PDHX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDHX→partner) and Y-score (partner→PDHX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.168	+1.459	.044	.012	3	2
UCEC	MEK1 →	+0.491	+2.321	<.001	<.001	3	2
UCEC	PCNA →	+0.254	+2.662	<.001	<.001	3	2
UCEC	Rad50 →	-0.191	-1.459	.015	.012	3	2
UCEC	S6_pS240_S244 →	+0.267	+2.000	.043	.030	3	2
UCEC	Shc_pY317 →	-0.138	-1.584	.004	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

FoxM1 by PDHX expression — UCEC

Explore this box plot interactively →