PDHA1

Across TCGA pan-cancer cohorts, PDHA1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PDHA1 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PDHA1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PDHA1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where PDHA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.820	0.644	.013	29	view →
LUAD	DFS	Quartile	II,III,IV	0.361	0.841	.007	6	view →
HNSC	DFS	Tertile	III,IV	0.830	0.522	.013	4	view →
GBM	OS	Median	All	0.849	0.781	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PDHA1–PDAC (DFS)

Open the PDAC breakdown →