PDHA1

Across TCGA patient cohorts, PDHA1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,536 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PDHA1-associated genes across cancer lineages are ITGB1, LGALS1, and CLEC11A. Each is linked with PDHA1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PDHA1-to-partner and partner-to-PDHA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDHA1 versus ITGB1 in OV, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDHA1→partner) and Y-score (partner→PDHA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ITGB1 →	-0.798	-0.468	<.001	<.001	3	6
GBM	LGALS1 →	-0.866	-0.380	<.001	<.001	3	5
OV	CLEC11A →	-1.012	-0.388	.002	.002	3	5
OV	DSE →	-0.643	-0.448	.003	<.001	3	5
COAD	LOX →	-1.180	-0.368	<.001	<.001	3	5
OV	CALU →	-0.627	-0.454	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,536 associations by consensus.

PDHA1 vs ITGB1 — OV

Explore this scatter interactively →