PDHA1

Across TCGA patient cohorts, PDHA1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDHA1-associated genes across cancer lineages are C-Raf, A-Raf_pS299, and FOXO3a_pS318_S321. Each is linked with PDHA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDHA1-to-partner and partner-to-PDHA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by PDHA1-low versus PDHA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDHA1→partner) and Y-score (partner→PDHA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.146	+2.000	.003	.003	3	3
UCEC	A-Raf_pS299 →	-0.102	-1.700	.015	.042	3	2
UCEC	FOXO3a_pS318_S321 →	-0.134	-2.160	.002	.003	3	1
UCEC	ACC1 →	+0.252	+1.750	.049	.049	3	1
UCEC	JNK_pT183_Y185 →	-0.210	-3.807	<.001	<.001	3	1
UCEC	JNK2 →	+0.243	+2.000	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

C-Raf by PDHA1 expression — UCEC

Explore this box plot interactively →