PDHA1

Across TCGA cell cohorts, PDHA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,374 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PDHA1-associated GO terms across cancer lineages are Cristae formation, Growth hormone secretion, and Inner mitochondrial membrane organization. Each is linked with PDHA1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PDHA1-to-partner and partner-to-PDHA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cristae formation grouped by PDHA1-low versus PDHA1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDHA1→partner) and Y-score (partner→PDHA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Cristae formation →	+0.156	+0.993	<.001	<.001	3	14
BLOOD_Myeloma	Growth hormone secretion →	+0.210	+0.910	.001	.002	3	13
LUNG_SCLC	Inner mitochondrial membrane organization →	+0.072	+0.631	.001	.002	3	13
BLOOD_Lymphoma	Mitochondrial ribosome assembly →	+0.099	+1.014	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Lagging strand elongation →	+0.118	+0.862	.002	<.001	3	11
PANCREAS	Protein import into mitochondrial matrix →	+0.091	+0.994	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,374 associations by consensus.

Cristae formation by PDHA1 expression — PANCREAS

Explore this box plot interactively →