PDGFRL

Across TCGA patient cohorts, PDGFRL mutation is significantly associated with the RNA expression of many other genes, with 1,004 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDGFRL-associated genes across cancer lineages are RPUSD2, TRUB2, and MCRIP2. Each is linked with PDGFRL in more than 1 cancer types. Because this analysis shows association rather than direction, both PDGFRL-to-partner and partner-to-PDGFRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPUSD2 grouped by PDGFRL-low versus PDGFRL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFRL→partner) and Y-score (partner→PDGFRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPUSD2 →	+0.358	+2.855	.003	.001	3	2
UCEC	TRUB2 →	+0.395	+3.064	<.001	<.001	3	2
UCEC	MCRIP2 →	+0.485	+2.716	.003	.003	3	2
UCEC	IMP3 →	+0.304	+2.584	.009	.001	3	2
LUSC	FGF7P7 →	+0.252	+5.792	<.001	.003	3	2
LUSC	RNA5SP413 →	+1.176	+6.081	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,004 associations by consensus.

RPUSD2 by PDGFRL expression — UCEC

Explore this box plot interactively →