PDGFRL

Across TCGA patient cohorts, PDGFRL mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDGFRL-associated genes across cancer lineages are PCNA, EGFR_pY1068, and ERK2. Each is linked with PDGFRL in more than 1 cancer types. Because this analysis shows association rather than direction, both PDGFRL-to-partner and partner-to-PDGFRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PDGFRL-low versus PDGFRL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFRL→partner) and Y-score (partner→PDGFRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.224	+2.999	.014	.035	3	2
UCEC	EGFR_pY1068 →	-0.221	-2.222	.038	.011	3	1
UCEC	ERK2 →	+0.207	+1.700	.011	.044	3	1
UCEC	Heregulin →	-0.126	-2.986	.016	.035	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.518	+2.009	.016	.017	3	1
UCEC	MEK1 →	+0.378	+3.459	.014	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PCNA by PDGFRL expression — UCEC

Explore this box plot interactively →