PDGFRL

Across TCGA cell cohorts, PDGFRL RNA expression is significantly associated with the go_rna of many other GO terms, with 2,798 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PDGFRL-associated GO terms across cancer lineages are Negative regulation of amyloid fibril formation, Positive regulation of protein exit from endoplasmic reticulum, and Positive regulation of B cell activation. Each is linked with PDGFRL in more than 8 cancer types. Because this analysis shows association rather than direction, both PDGFRL-to-partner and partner-to-PDGFRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of amyloid fibril formation grouped by PDGFRL-low versus PDGFRL-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFRL→partner) and Y-score (partner→PDGFRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of amyloid fibril formation →	+0.253	+1.368	<.001	.001	3	9
SOFT_TISSUE	Positive regulation of protein exit from endoplasmic reticulum →	+0.093	+1.330	<.001	.004	3	8
BLOOD_Lymphoma	Positive regulation of B cell activation →	-0.079	-0.682	<.001	.004	3	7
BONE	Energy derivation by oxidation of organic compounds →	+0.052	+1.409	.001	<.001	3	7
BLOOD_Lymphoma	Regulation of protein exit from endoplasmic reticulum →	+0.067	+0.625	.006	.009	3	7
KIDNEY	Golgi vesicle transport →	+0.040	+0.995	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,798 associations by consensus.

Negative regulation of amyloid fibril formation by PDGFRL expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →