PDGFRB

Across TCGA patient cohorts, PDGFRB mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDGFRB-associated genes across cancer lineages are eEF2, FoxM1, and eIF4E. Each is linked with PDGFRB in more than 2 cancer types. Because this analysis shows association rather than direction, both PDGFRB-to-partner and partner-to-PDGFRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PDGFRB-low versus PDGFRB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFRB→partner) and Y-score (partner→PDGFRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eEF2 →	+0.249	+2.186	.043	.032	3	3
SKCM	FoxM1 →	+0.191	+1.765	.012	.013	3	3
COAD	eIF4E →	+0.197	+3.182	.005	.009	3	3
COAD	ATM →	-0.588	-2.106	<.001	.018	3	3
SKCM	MYH11 →	-0.733	-3.321	.022	.009	3	2
UCEC	STAT3_pY705 →	-0.261	-1.504	.001	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eEF2 by PDGFRB expression — SKCM

Explore this box plot interactively →