PDGFD

Across TCGA pan-cancer cohorts, PDGFD Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PDGFD data layer compared with 21 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PDGFD Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDGFD expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, UCEC, and STAD are the cancer types where PDGFD Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.455	0.793	<.001	27	view →
UCEC	DFS	Median	All	1.000	0.618	.005	16	view →
STAD	OS	Median	All	0.224	0.729	.007	15	view →
ESCA	OS	Median	All	0.198	0.872	.003	12	view →
LUAD	OS	Median	All	0.378	0.699	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PDGFD–COAD (DFS)

Open the COAD breakdown →