PDGFD

Across TCGA patient cohorts, PDGFD mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDGFD-associated genes across cancer lineages are INPP4B, MEK1, and p38-MAPK_pT180_Y182. Each is linked with PDGFD in more than 1 cancer types. Because this analysis shows association rather than direction, both PDGFD-to-partner and partner-to-PDGFD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by PDGFD-low versus PDGFD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFD→partner) and Y-score (partner→PDGFD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.281	-2.459	.023	.018	3	2
UCEC	MEK1 →	+0.421	+2.087	.002	.005	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.417	-2.000	.015	.030	3	2
UCEC	PCNA →	+0.231	+3.321	.005	.009	3	2
UCEC	S6_pS240_S244 →	+0.340	+3.169	.029	.019	3	2
UCEC	TFRC →	+0.418	+2.087	.040	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

INPP4B by PDGFD expression — UCEC

Explore this box plot interactively →