PDGFC

Across TCGA pan-cancer cohorts, PDGFC mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PDGFC data layer compared with 21 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PDGFC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDGFC expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

PDAC, LSCC, and UCEC are the cancer types where PDGFC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.658	0.845	<.001	37	view →
LSCC	DFS	Quartile	All	0.331	1.000	.002	6	view →
UCEC	DFS	Tertile	II,III,IV	0.881	0.502	.036	4	view →
CCRCC	OS	Median	All	0.332	0.934	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PDGFC–PDAC (DFS)

Open the PDAC breakdown →