PDGFC

Across TCGA patient cohorts, PDGFC mutation is significantly associated with the RNA expression of many other genes, with 5,808 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDGFC-associated genes across cancer lineages are MST1R, RBAK-RBAKDN, and MICE. Each is linked with PDGFC in more than 2 cancer types. Because this analysis shows association rather than direction, both PDGFC-to-partner and partner-to-PDGFC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MST1R grouped by PDGFC-low versus PDGFC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFC→partner) and Y-score (partner→PDGFC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MST1R →	+1.206	+2.874	<.001	<.001	3	3
UCEC	RBAK-RBAKDN →	+0.082	+1.682	<.001	.003	3	2
UCEC	MICE →	+0.264	+2.721	.002	.003	3	2
UCEC	CYFIP1 →	+0.560	+2.424	<.001	<.001	3	2
UCEC	ZNF658 →	+0.264	+2.254	.002	.005	3	2
UCEC	ZNF280B →	+0.699	+2.885	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,808 associations by consensus.

MST1R by PDGFC expression — UCEC

Explore this box plot interactively →