PDGFC

Across TCGA cell cohorts, PDGFC RNA expression is significantly associated with the go_rna of many other GO terms, with 6,329 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PDGFC-associated GO terms across cancer lineages are Regulation of focal adhesion assembly, Synaptic transmission, glycinergic, and Regulation of cell-substrate junction assembly. Each is linked with PDGFC in more than 12 cancer types. Because this analysis shows association rather than direction, both PDGFC-to-partner and partner-to-PDGFC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of focal adhesion assembly grouped by PDGFC-low versus PDGFC-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFC→partner) and Y-score (partner→PDGFC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of focal adhesion assembly →	+0.138	+1.869	<.001	<.001	3	13
OVARY	Synaptic transmission, glycinergic →	+1.371	+1.967	<.001	<.001	3	13
BONE	Regulation of cell-substrate junction assembly →	+0.138	+1.869	<.001	<.001	3	13
URINARY_TRACT	Peptidyl-lysine oxidation →	+1.598	+2.274	<.001	<.001	3	13
BONE	Regulation of cell-matrix adhesion →	+0.132	+1.792	<.001	<.001	3	12
BONE	Regulation of cell-substrate junction organization →	+0.130	+1.688	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,329 associations by consensus.

Regulation of focal adhesion assembly by PDGFC expression — BONE

Explore this box plot interactively →