PDGFC

Across TCGA cell cohorts, PDGFC mutation is significantly associated with the RNA expression of many other genes, with 261 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDGFC-associated genes across cancer lineages are PIM2, PPIF, and MS4A4A. Each is linked with PDGFC in more than 1 cancer types. Because this analysis shows association rather than direction, both PDGFC-to-partner and partner-to-PDGFC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIM2 grouped by PDGFC-low versus PDGFC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFC→partner) and Y-score (partner→PDGFC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PIM2 →	+0.546	+3.212	.003	.006	3	1
LARGE_INTESTINE	PPIF →	+0.624	+3.212	.002	.006	3	1
LARGE_INTESTINE	MS4A4A →	+0.132	+2.263	<.001	.008	3	1
LARGE_INTESTINE	UHRF1BP1L →	+0.586	+3.212	.004	.006	3	1
LARGE_INTESTINE	PCCB →	+0.637	+3.299	.001	.004	3	1
LARGE_INTESTINE	ALDH6A1 →	+1.071	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 261 associations by consensus.

PIM2 by PDGFC expression — LARGE_INTESTINE

Explore this box plot interactively →