Across TCGA pan-cancer cohorts, PDGFA mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PDGFA data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PDGFA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PDGFA expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where PDGFA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.907	0.498	.003	29	view →
PDAC	DFS	Median	IV	0.934	0.282	.024	8	view →
LSCC	OS	Tertile	All	0.685	0.959	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: PDGFA tumor-vs-normal RNA expression · all PDGFA data types