Across TCGA patient cohorts, PDGFA mutation is significantly associated with the RNA expression of many other genes, with 555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDGFA-associated genes across cancer lineages are RNA5SP411, TNPO1P2, and RNA5SP421. Each is linked with PDGFA in more than 1 cancer types. Because this analysis shows association rather than direction, both PDGFA-to-partner and partner-to-PDGFA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFA→partner) and Y-score (partner→PDGFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+0.836	+2.201	.008	.004	3	2
UCEC	TNPO1P2 →	+0.046	+2.136	.006	.004	3	2
UCEC	RNA5SP421 →	+0.696	+2.411	<.001	.002	3	2
UCEC	TOMM22 →	+0.499	+3.491	.002	.002	3	1
UCEC	JOSD1 →	+0.562	+2.700	.001	.006	3	1
UCEC	MIEF1 →	+0.532	+3.601	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 555 associations by consensus.

Exploration

PDGFA survival (RNA) · tumor vs normal (RNA) · all PDGFA data types