Across TCGA patient cohorts, PDGFA mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDGFA-associated genes across cancer lineages are Caspase-7-cleavedD198, p62 Lck ligand, and Caspase-8. Each is linked with PDGFA in more than 1 cancer types. Because this analysis shows association rather than direction, both PDGFA-to-partner and partner-to-PDGFA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFA→partner) and Y-score (partner→PDGFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.677	+2.827	.023	.035	3	2
UCEC	p62 Lck ligand →	+0.663	+3.331	<.001	.005	3	1
UCEC	Caspase-8 →	-0.318	-2.321	.011	.034	3	1
UCEC	CDK1 →	+0.191	+3.013	.012	.018	3	1
UCEC	c-Jun_pS73 →	-0.198	-2.321	.013	.035	3	1
UCEC	Cyclin-B1 →	+1.130	+3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

PDGFA survival (RNA) · tumor vs normal (RNA) · all PDGFA data types