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Across TCGA pan-cancer cohorts, PDF mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PDF data layer compared with 27 for mass-spec protein.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher PDF mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PDF expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

GBM, CCRCC, and HNSC are the cancer types where PDF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.972	0.727	.001	18	view →
CCRCC	DFS	Quartile	III,IV	0.501	0.867	.023	8	view →
HNSC	OS	Median	All	0.801	0.601	.013	7	view →
COAD	DFS	Median	IV	0.565	1.000	.036	6	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.520	.043	4	view →
PDAC	DFS	Median	IV	0.190	0.749	.038	3	view →
LSCC	OS	Median	All	0.800	1.000	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PDF–GBM (OS)

Open the GBM breakdown →