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Across TCGA pan-cancer cohorts, PDF mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PDF’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PDF mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PDF is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and PDAC are the cancer types where PDF tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDF mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	−0.745	<.001	12	view →
HNSC	All	All	−0.427	<.001	11	view →
PDAC	Male	All	−0.848	<.001	8	view →
COAD	Male	II,III,IV	−0.193	.020	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PDF–CCRCC

Open the CCRCC breakdown →