PDF

Across TCGA patient cohorts, PDF protein abundance is significantly associated with the RNA expression of many other genes, with 9,387 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PDF-associated genes across cancer lineages are UTP4, NIP7, and TERF2. Each is linked with PDF in more than 5 cancer types. Because this analysis shows association rather than direction, both PDF-to-partner and partner-to-PDF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDF versus UTP4 in LSCC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDF→partner) and Y-score (partner→PDF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UTP4 →	+0.546	+0.359	<.001	<.001	3	6
OV	NIP7 →	+0.516	+0.459	<.001	<.001	3	5
HNSC	TERF2 →	+0.481	+0.325	.002	.003	3	4
GBM	VPS4A →	+0.356	+0.324	.001	.001	3	4
GBM	TNS3 →	-0.723	-0.230	<.001	<.001	3	4
LUAD	RANBP10 →	+0.448	+0.341	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,387 associations by consensus.

PDF vs UTP4 — LSCC

Explore this scatter interactively →