PDF

Across TCGA cell cohorts, PDF RNA expression is significantly associated with the go_rna of many other GO terms, with 4,533 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PDF-associated GO terms across cancer lineages are Peptidyl-methionine modification, Mitochondrial large ribosomal subunit assembly, and Vesicle uncoating. Each is linked with PDF in more than 19 cancer types. Because this analysis shows association rather than direction, both PDF-to-partner and partner-to-PDF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-methionine modification grouped by PDF-low versus PDF-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDF→partner) and Y-score (partner→PDF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Peptidyl-methionine modification →	+0.346	+1.252	<.001	<.001	3	20
BLOOD_Lymphoma	Mitochondrial large ribosomal subunit assembly →	+0.128	+1.292	<.001	<.001	3	14
LUNG_SCLC	Vesicle uncoating →	+0.150	+1.056	<.001	<.001	3	13
BLOOD_Lymphoma	Mitochondrial ribosome assembly →	+0.107	+1.375	<.001	<.001	3	12
LARGE_INTESTINE	mRNA alternative polyadenylation →	+0.082	+0.978	<.001	<.001	3	12
BLOOD_Lymphoma	Ribosomal large subunit assembly →	+0.123	+1.276	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,533 associations by consensus.

Peptidyl-methionine modification by PDF expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →