PDE8B

Across TCGA patient cohorts, PDE8B protein abundance is significantly associated with the RNA expression of many other genes, with 3,965 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PDE8B-associated genes across cancer lineages are SNRPD3, PRODH, and GRK3. Each is linked with PDE8B in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE8B-to-partner and partner-to-PDE8B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE8B versus SNRPD3 in GBM, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE8B→partner) and Y-score (partner→PDE8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNRPD3 →	+0.477	+1.083	<.001	<.001	3	1
GBM	PRODH →	+1.260	+1.128	<.001	<.001	3	1
GBM	GRK3 →	+0.904	+1.306	<.001	<.001	3	1
GBM	SEZ6L →	+2.248	+1.112	<.001	<.001	3	1
GBM	HPS4 →	+0.334	+0.789	.004	.005	3	1
GBM	SRRD →	+0.438	+1.123	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,965 associations by consensus.

PDE8B vs SNRPD3 — GBM

Explore this scatter interactively →