PDE8B

Across TCGA patient cohorts, PDE8B mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE8B-associated genes across cancer lineages are ATM, C-Raf, and Shc_pY317. Each is linked with PDE8B in more than 4 cancer types. Because this analysis shows association rather than direction, both PDE8B-to-partner and partner-to-PDE8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PDE8B-low versus PDE8B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE8B→partner) and Y-score (partner→PDE8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.588	-2.169	<.001	<.001	3	5
SKCM	C-Raf →	+0.155	+2.824	.010	.034	3	4
UCEC	Shc_pY317 →	-0.194	-1.807	<.001	.003	3	3
UCEC	GAPDH →	+0.455	+2.087	.006	.005	3	3
UCEC	Bax →	+0.170	+1.415	.022	.010	3	3
UCEC	Caspase-7-cleavedD198 →	+0.881	+1.893	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

ATM by PDE8B expression — UCEC

Explore this box plot interactively →