PDE8B

Across TCGA cell cohorts, PDE8B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,347 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDE8B-associated GO terms across cancer lineages are Lysosomal lumen acidification, Positive regulation of maintenance of sister chromatid cohesion, and Positive regulation of maintenance of mitotic sister chromatid cohesion. Each is linked with PDE8B in more than 7 cancer types. Because this analysis shows association rather than direction, both PDE8B-to-partner and partner-to-PDE8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lysosomal lumen acidification grouped by PDE8B-low versus PDE8B-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE8B→partner) and Y-score (partner→PDE8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Lysosomal lumen acidification →	+0.090	+0.392	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Positive regulation of maintenance of sister chromatid cohesion →	+0.060	+0.344	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Positive regulation of maintenance of mitotic sister chromatid cohesion →	+0.060	+0.344	<.001	<.001	3	7
OESOPHAGUS	Regulation of syncytium formation by plasma membrane fusion →	+0.094	+0.370	.001	<.001	3	7
OESOPHAGUS	Mitotic cytokinesis →	+0.060	+0.324	.005	.003	3	7
OESOPHAGUS	Golgi vesicle transport →	+0.057	+0.293	.009	.009	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,347 associations by consensus.

Lysosomal lumen acidification by PDE8B expression — CNS

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