PDE8B

Across TCGA cell cohorts, PDE8B mutation is significantly associated with the RNA expression of many other genes, with 518 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE8B-associated genes across cancer lineages are HJV, TRPC5OS, and KRT71. Each is linked with PDE8B in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE8B-to-partner and partner-to-PDE8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HJV grouped by PDE8B-low versus PDE8B-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE8B→partner) and Y-score (partner→PDE8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HJV →	+0.015	+3.584	.004	.009	3	1
URINARY_TRACT	TRPC5OS →	+0.031	+3.584	.008	.009	3	1
BLOOD_Lymphoma	KRT71 →	+0.007	+4.058	<.001	.009	3	1
LUNG_NSCLC_LUAD	COX4I2 →	+0.050	+3.813	<.001	.001	3	1
LUNG_NSCLC_LUAD	IL1F10 →	+0.118	+2.989	.007	.007	3	1
LUNG_NSCLC_LUAD	TEX33 →	+0.015	+3.944	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 518 associations by consensus.

HJV by PDE8B expression — URINARY_TRACT

Explore this box plot interactively →