PDE8A

Across TCGA pan-cancer cohorts, PDE8A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PDE8A data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PDE8A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PDE8A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where PDE8A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	1.000	0.836	.004	28	view →
PDAC	DFS	Quartile	II,III,IV	0.821	0.493	.019	11	view →
LSCC	DFS	Quartile	All	0.840	0.999	.024	10	view →
LUAD	OS	Median	II,III,IV	0.293	0.837	<.001	8	view →
GBM	OS	Tertile	All	0.200	0.547	.015	5	view →
UCEC	DFS	Quartile	All	0.825	1.000	.047	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PDE8A–CCRCC (DFS)

Open the CCRCC breakdown →