PDE7B

Across TCGA patient cohorts, PDE7B mutation is significantly associated with the RNA expression of many other genes, with 4,126 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE7B-associated genes across cancer lineages are ALAS1, LINC02319, and RNU6-539P. Each is linked with PDE7B in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE7B-to-partner and partner-to-PDE7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALAS1 grouped by PDE7B-low versus PDE7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE7B→partner) and Y-score (partner→PDE7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ALAS1 →	+0.605	+3.906	<.001	<.001	3	3
LUSC	LINC02319 →	+0.324	+3.171	<.001	.006	3	3
SKCM	RNU6-539P →	+0.134	+1.715	.005	.006	3	3
UCEC	PKN3 →	+0.915	+4.818	<.001	<.001	3	3
UCEC	MSANTD3 →	+0.646	+2.273	<.001	<.001	3	3
UCEC	COX10 →	+0.467	+3.115	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,126 associations by consensus.

ALAS1 by PDE7B expression — UCEC

Explore this box plot interactively →