PDE7B

Across TCGA patient cohorts, PDE7B mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE7B-associated genes across cancer lineages are MEK1, 14-3-3_beta, and Ku80. Each is linked with PDE7B in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE7B-to-partner and partner-to-PDE7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PDE7B-low versus PDE7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE7B→partner) and Y-score (partner→PDE7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.392	+2.321	.002	.001	3	2
UCEC	14-3-3_beta →	-0.097	-1.571	.007	.019	3	2
SKCM	Ku80 →	+0.294	+3.321	.005	.009	3	2
UCEC	Myosin-IIa_pS1943 →	+0.225	+1.939	.002	.003	3	2
UCEC	PDCD4 →	-0.469	-1.584	.005	.019	3	2
UCEC	ASNS →	+0.379	+1.906	.003	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

MEK1 by PDE7B expression — UCEC

Explore this box plot interactively →