PDE7B

Across TCGA cell cohorts, PDE7B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,733 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PDE7B-associated GO terms across cancer lineages are Positive regulation of stress fiber assembly, Elastin metabolic process, and Regulation of transforming growth factor beta receptor signaling pathway. Each is linked with PDE7B in more than 8 cancer types. Because this analysis shows association rather than direction, both PDE7B-to-partner and partner-to-PDE7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of stress fiber assembly grouped by PDE7B-low versus PDE7B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE7B→partner) and Y-score (partner→PDE7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of stress fiber assembly →	+0.122	+1.047	.002	.003	3	9
SOFT_TISSUE	Elastin metabolic process →	+0.166	+1.199	<.001	.002	3	8
SOFT_TISSUE	Regulation of transforming growth factor beta receptor signaling pathway →	+0.051	+0.946	<.001	<.001	3	8
SKIN	Positive regulation of protein exit from endoplasmic reticulum →	+0.126	+1.054	<.001	.002	3	8
SOFT_TISSUE	Establishment of protein localization to extracellular region →	+0.076	+1.059	<.001	<.001	3	7
SOFT_TISSUE	Biological process involved in symbiotic interaction →	+0.108	+1.329	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,733 associations by consensus.

Positive regulation of stress fiber assembly by PDE7B expression — BONE

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