PDE7B

Across TCGA cell cohorts, PDE7B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PDE7B-associated genes across cancer lineages are GAGE12D, GAGE12C, and MYH4. Each is linked with PDE7B in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE7B-to-partner and partner-to-PDE7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12D grouped by PDE7B-low versus PDE7B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE7B→partner) and Y-score (partner→PDE7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GAGE12D →	+3.937	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	GAGE12C →	+2.657	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	MYH4 →	+0.013	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	SPANXN2 →	+0.013	+6.266	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GAGE12D by PDE7B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →