Across TCGA pan-cancer cohorts, PDE7A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PDE7A data layer compared with 21 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher PDE7A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PDE7A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

READ, LIHC, and HNSC are the cancer types where PDE7A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.166	0.830	<.001	18	view →
LIHC	OS	Median	All	0.144	0.688	.013	9	view →
HNSC	DFS	Median	IV	0.187	0.669	.043	3	view →
UCEC	DFS	Median	II,III,IV	0.896	0.308	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PDE7A tumor-vs-normal RNA expression · all PDE7A data types