Across TCGA patient cohorts, PDE7A protein abundance is significantly associated with the RNA expression of many other genes, with 4,509 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PDE7A-associated genes across cancer lineages are SLC25A35, CDHR3, and THEMIS2. Each is linked with PDE7A in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE7A-to-partner and partner-to-PDE7A results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE7A→partner) and Y-score (partner→PDE7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC25A35 →	-1.382	-0.511	.008	.008	3	2
UCEC	CDHR3 →	-1.418	-0.538	.004	.004	3	2
LSCC	THEMIS2 →	+0.778	+0.410	<.001	<.001	3	2
UCEC	TNF →	+1.497	+0.827	.001	.003	3	2
UCEC	MTND3P21 →	-0.644	-0.584	<.001	<.001	3	2
UCEC	WAKMAR2 →	+0.657	+0.745	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,509 associations by consensus.

Exploration

PDE7A survival (RNA) · tumor vs normal (RNA) · all PDE7A data types