Across TCGA patient cohorts, PDE7A mutation is significantly associated with the RNA expression of many other genes, with 1,228 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE7A-associated genes across cancer lineages are PHACTR3-AS1, H3Y1, and DEFB127. Each is linked with PDE7A in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE7A-to-partner and partner-to-PDE7A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE7A→partner) and Y-score (partner→PDE7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PHACTR3-AS1 →	+0.081	+5.912	<.001	.002	3	2
UCEC	H3Y1 →	+1.222	+2.208	<.001	<.001	3	2
BLCA	DEFB127 →	+0.087	+4.788	<.001	.006	3	2
UCEC	GCNT2P1 →	+0.263	+3.502	.001	.002	3	2
UCEC	TRIM53CP →	+0.330	+2.272	.003	<.001	3	2
HNSC	DHFRP3 →	+0.095	+5.822	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,228 associations by consensus.

Exploration

PDE7A survival (RNA) · tumor vs normal (RNA) · all PDE7A data types