Across TCGA patient cohorts, PDE7A mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE7A-associated genes across cancer lineages are Rab11, 14-3-3_beta, and eIF4E. Each is linked with PDE7A in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE7A-to-partner and partner-to-PDE7A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE7A→partner) and Y-score (partner→PDE7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab11 →	-0.152	-2.321	.011	.006	3	2
UCEC	14-3-3_beta →	-0.108	-2.432	.009	.018	3	1
UCEC	eIF4E →	+0.191	+3.000	.028	.001	3	1
UCEC	ERK2 →	+0.191	+2.459	.016	.019	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.519	+2.009	.003	.017	3	1
UCEC	JNK2 →	+0.338	+3.000	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

PDE7A survival (RNA) · tumor vs normal (RNA) · all PDE7A data types