PDE6B-AS1

Across TCGA pan-cancer cohorts, PDE6B-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PDE6B-AS1 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PDE6B-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PDE6B-AS1 expression acts as an unfavorable survival marker, although some lineages such as CESC and LUAD show a favorable association.

CESC, LUAD, and SKCM are the cancer types where PDE6B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	II,III,IV	0.787	0.456	<.001	106	view →
LUAD	OS	Median	All	0.507	0.248	<.001	86	view →
SKCM	OS	Median	All	0.444	0.273	<.001	63	view →
ACC	DFS	Tertile	All	0.165	0.681	<.001	57	view →
PAAD	DFS	Tertile	All	0.536	0.229	.002	54	view →
LGG	DFS	Median	All	0.666	0.805	<.001	45	view →
KIRC	DFS	Quartile	All	0.430	0.721	<.001	43	view →
MESO	OS	Median	II,III,IV	0.201	0.378	.012	35	view →
UCEC	DFS	Quartile	All	0.501	0.796	<.001	28	view →
BLCA	OS	Tertile	III,IV	0.758	0.595	.007	27	view →
CHOL	DFS	Median	IV	0.251	0.794	.010	9	view →
LIHC	OS	Quartile	II,III,IV	0.429	0.655	.006	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PDE6B-AS1–CESC (OS)

Open the CESC breakdown →