PDE6A

Across TCGA patient cohorts, PDE6A protein abundance is significantly associated with the RNA expression of many other genes, with 10,607 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PDE6A-associated genes across cancer lineages are USP8, IVD, and SPPL2A. Each is linked with PDE6A in more than 6 cancer types. Because this analysis shows association rather than direction, both PDE6A-to-partner and partner-to-PDE6A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE6A versus USP8 in BRCA, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6A→partner) and Y-score (partner→PDE6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	USP8 →	+0.524	+0.253	<.001	<.001	3	7
COAD	IVD →	+0.643	+0.172	<.001	<.001	3	6
COAD	SPPL2A →	+0.467	+0.155	<.001	<.001	3	6
BRCA	WDR61 →	+0.421	+0.243	.002	<.001	3	6
BRCA	LEO1 →	+0.616	+0.282	<.001	<.001	3	6
OV	NDUFAF1 →	+0.445	+0.204	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,607 associations by consensus.

PDE6A vs USP8 — BRCA

Explore this scatter interactively →